Question
A 42 year old male presents with painful flaccid vesicles on face & oral mucosa with asymmetric distribution . Immunofluorescence shows intercellular IgG deposition in epidermis . Diagnosis is?
| A. |
Bullous pemphigoid
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| B. |
Bullous SLE
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| C. |
Herpes zoster
|
| D. |
Pemphigus vulgaris
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Show Answer
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Correct Answer � D
Explanation
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|
Correct answer : d
Pemphigus vulgaris :
It is the most common type of pemphigus.
Autoimmune blistering disorder with IgG autoantibodies against Dsg (Desmogleins) , which is a desmosomal protein present in desmosomes /intercellular substances leading to separation of keratinocytes .
Affects 40 years ,starts as buccal mucosal erosions followed by superficial &
flaccid vesicles and bullae.
Pruritus is absent. Acantholysis is seen.
Row of tombstones appearance seen in Histopath examination.
Immunofluorescence shows intercellular IgG deposition in epidermis in a Fishnet pattern .
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