MCQ – 88580


91. In an experiment, various soluble mediators are added to a cell culture containing epidermal cells to determine which of the mediators might be useful for promoting epidermal cell growth. When epidermal growth factor (EGF) is added, it binds to epidermal cell surface receptors, inducing RAS protein activation, with subsequent transcription factor translocation andDNA transcription activation. This effect in the epidermal cells is most likely to be mediated through which of the following intracellular pathways?


Calcium ion channel


Cyclic AMP


Cyclin-dependent kinase


Mitogen-activated protein kinase

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