Question
85-year-old woman with Nikolsky sign negative, tense blisters on thigh and trunk, lesions come on and off on normal skin as well as over urticarial plaques. What is the cause:
| A. |
Pemphigus vulgaris
|
| B. |
Bullous Pemphigoid
|
| C. |
Lichen planus
|
| D. |
Dermatitis herpetiformis
|
Show Answer
|
Correct Answer � B
Explanation
|
|
Correct answer : b
Bullous Pemphigoid :
It is a chronic autoimmune Subepidermal NON acantholytic blistering disorder where IgG autoantibodies are formed against bullous pemphigoid antigen 1 & 2 (BP 180/BPAG 2 > BP 230 / BPAG 1).
Clinical features :
Elderly (60-80years) with itchy tense haemorrhagic blisters (overlying roof settles down , sticking to the base which later heals with scar or milia formation , having perilesional urticarial skin with erythema .
Lesions have predilection for flexural areas on the thigh , groin , trunk & axilla . blisters may heal with hypopigmentation.
Nikolsky sign negative.
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