MCQ – 88623


102. A 69-year-old man is scheduled for surgery, but the procedure is canceled because of abnormal findings in the preoperative blood work. A CBC shows leukocytosis (WBC = 124,000/mL), consisting mainly of maturing neutrophils. Basophilia and eosinophilia are also observed. The platelet count is 820,000/μL. A t(9;22)(q34;q11) translocation is documented. A bone marrow biopsy is shown in the image. Which of the following best characterizes the pathogenesis of the hematologic condition encountered in this patient?


Blocked differentiation of pre-B cells


Blocked differentiation of pre-T cells


Maturational arrest of lymphoid progenitor stem cells


Transformation of a pluripotent bone marrow stem cell

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