Antibody-mediated platelet destruction
Clonal plasma cell circulating paraprotein
Decreased susceptibility to complement-mediated lysis
Defect in the platelet cytoskeleton
Answer : A Antibody-mediated platelet destruction
In common with idiopathic thrombocytopenic purpura and certain drug-induced thrombocytopenias, systemic lupus erythematosus is associated with increased platelet destruction due to immune-mediated damage and removal of circulating platelets (antibody-mediated platelet destruction). The other choices do not represent immune destruction of platelets.