MCQ – 88639

Question

A 25-year-old woman with a history of systemic lupus erythematosus presents with diffuse petechiae and fatigue. Physical examination demonstrates lymphadenopathy and splenomegaly. Laboratory findings include normocytic anemia (hemoglobin = 6.1 g/dL) and thrombocytopenia (30,000/mL). Which of the following is the most likely underlying mechanism in the development of thrombocytopenia in this patient?

A.

 Antibody-mediated platelet destruction

B.

Clonal plasma cell circulating paraprotein

C.

Decreased susceptibility to complement-mediated lysis

D.

Defect in the platelet cytoskeleton

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