Langerhans cell histiocytosis
Answer : B Langerhans cell histiocytosis
LCH refers to a spectrum of uncommon proliferative disorders of Langerhans cells. The disease ranges from asymptomatic involvement of a single site, such as bone or lymph nodes, to an aggressive systemic disorder that involves multiple organs.
There is clinical heterogeneity of LCH; eosinophilic granuloma (75% of all cases) is a localized, usually self-limited disorder of older children and young adults; Hand-Schuller-Christian disease is a multifocal and typically indolent disorder, usually in children between 2 and 5 years of age; and Letterer-Siwe disease (fewer than 10% of cases) is an acute, disseminated variant of LCH in infants and children younger than 2 years of age.Organs involved by LCH include the skin (seborrheic or eczematoid dermatitis), lymph nodes, spleen, liver, lungs, and bone marrow. Otitis media is a common finding. Painful lytic lesions bones are common.
Proptosis may complicate infiltration of the orbit. The classic triad of diabetes insipidus, proptosis, and defects in membranous bones characterizes Hand Schuller-Christian disease.
Hodgkin lymphoma often features eosinophils but does not have this clinical presentation.