A 44-year-old woman is recently diagnosed with breast cancer and undergoes a mastectomy. Which of the following features is most likely to be important in determining response to tamoxifen therapy?
|A.||metastases confined to the liver|
patient more than 5 years premenopausal
androgen receptors on the tumor cell membrane
the tumor has progesterone receptors (PR)
Approximately, one-third of unselected women with metastatic breast cancer will respond to tamoxifen. The presence of estrogen receptors (ER) or PR improves the likelihood of response. If the tumor is both ER and PR positive, the response rate is 70%.