Question
A patient with aplastic anemia receives a bone marrow transplant from a human lymphocyte antigen (HLA)-matched sister. Which of the following is the most likely complication of allogeneic bone marrow transplantation?
| A. |
graft-versus-host disease
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| B. |
graft failure
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| C. |
radiation sickness
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| D. |
development of leukemia
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Show Answer
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Correct Answer � A
Explanation
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Ans. (A)
Graft-versus-host disease is a frequent complication of hematopoietic cell transplantation. It is caused by a reaction of immunologically competent donor-derived T cells that react with recipient tissue antigens. It can be acute or chronic.
Numerous treatment regimens involving methotrexate, glucocorticoids, cyclosporine, and
Other drugs are used in treatment.
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