A patient with aplastic anemia receives a bone marrow transplant from a human lymphocyte antigen (HLA)-matched sister. Which of the following is the most likely complication of allogeneic bone marrow transplantation?
development of leukemia
Graft-versus-host disease is a frequent complication of hematopoietic cell transplantation. It is caused by a reaction of immunologically competent donor-derived T cells that react with recipient tissue antigens. It can be acute or chronic.
Numerous treatment regimens involving methotrexate, glucocorticoids, cyclosporine, and
Other drugs are used in treatment.