Question
An 81-year-old man presents with pallor, glossitis, cheilitis, and vitiligo. Which of the following is the most likely diagnosis?
| A. |
sickle cell anemia
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| B. |
cold agglutinin syndrome
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| C. |
methemoglobinemia
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| D. |
pernicious anemia
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Show Answer
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Correct Answer � D
Explanation
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|
Ans. (D)
Glossitis and cheilitis result from vitamin deficiency affecting rapidly turning over tissues. Patients may complain of a “burning” tongue, and examination reveals atrophy of papillae, a deep red mucosa, and a “cobble-stone” appearance. Vitamin B12 administration rapidly relieves these symptoms. Vitiligo is caused by an associated autoimmune disorder.
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