Question
A 56-year-old woman is receiving chemotherapy for lymphoma for the past year. Her liver enzymes have been persistently elevated for the last 2 months. She has no prior history of chronic liver disease, and screening tests for viral hepatitis are negative. A liver biopsy indicates early hepatic fibrosis. select the most likely chemotherapeutic agent
| A. |
methotrexate
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| B. |
cytarabine
|
| C. |
5-fluorouracil (5-FU)
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| D. |
bleomycin
|
Show Answer
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Correct Answer � A
Explanation
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|
Ans. (A)
Liver toxicity is most common when methotrexate is used daily, such as for psoriasis. Myelosuppression and GI mucositis are the most common side effects of cancer therapy.
Methotrexate is an antineoplastic and immunosuppressive agent widely used in the therapy of leukemia, lymphoma, solid tumors, psoriasis, and rheumatoid arthritis. When given in high intravenous doses, methotrexate can cause acute elevations in serum enzymes, and long-term methotrexate therapy has been associated with frequent but mild elevations in serum liver enzymes and, more importantly, with the development of chronic liver injury, progressive fibrosis, cirrhosis, and portal hypertension.
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