Anti centromere antibodies
Primary Sjogren syndrome is a systemic autoimmune disorder most commonly presenting with sicca symptoms. Sicca refers to dryness most often involving the eyes and mouth due to inflammation and resultant pathology of the lacrimal and salivary glands.
Sjogren syndrome frequently occurs in conjunction with other autoimmune disorders, including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). In this setting, the authors will refer to it as secondary Sjogren or Sjogren’s-overlap syndrome. Therapies are directed toward replacing moisture at affected glandular sites and suppressing the autoimmune response locally as well as systemically.
Cevimeline is a cholinergic agonist used in the treatment of Sjogren syndrome.
Anti-SSA and anti-SSB are autoantibodies that are elevated in patients with Sjogren’s syndrome. Patients with systemic lupus erythematosus may also have elevations of these antibodies.