A 55-year-old woman presents with painless enlargement of the parotid glands, which began 6 months earlier. On examination, ocular dryness and cervical lymphadenopathy are present. Biopsy of the parotid gland is likely to show which of the following?
Lymphocytic and plasma cell infiltrate with ductal epithelial hyperplasia
Well-demarcated tumor consisting of a mixture of epithelial and myoepithelial cells dispersed within loose myxoid tissue
|C.||Inflammation with neutrophil predominance and necrosis of salivary ducts|
|D.||Coagulative necrosis of acini with squamous metaplasia of ducts|
Answer : A Lymphocytic and plasma cell infiltrate with ductal epithelial hyperpla
Characteristic pathologic findings in Sjögren’s syndrome include periductal and perivascular infiltration of lymphocytes.
As the disease progresses, extensive lymphocytic infiltration can lead to formation of lymphoid follicles with germinal centers.
With time, hyperplasia of the ductal epithelia can progress to atrophy of the acini, fibrosis, and hyalinization describes pleomorphic adenoma of the parotid gland, not Sjögren’s syndrome