Question
A lymph node biopsy shows large pleomorphic cells in a sinusoidal distribution (see image). Which of the following would support a diagnosis of anaplastic large cell lymphoma (ALCL)?
| A. |
Variable positivity with CD30
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| B. |
Positivity for Epstein-Barr virus
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| C. |
Positivity for cytotoxic granule-associated proteins such as TIA-1
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| D. |
Dim nuclear PAX5 positivity
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Show Answer
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Correct Answer � C
Explanation
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Answer : C Positivity for cytotoxic granule-associated proteins such as TIA-1
Diffuse and strong CD30 positivity is required for diagnosing anaplastic large cell lymphoma (ALCL). Other lymphomas, both B-cell and T-cell, may express some CD30.
Epstein-Barr virus is not associated with ALCL.
ALCL frequently expresses cytotoxic granule-associated proteins such as TIA-a.
ALCL is a T-cell lymphoma. Expression of B-cell markers such as PAX-5 in malignant cells supports the diagnosis of a B-cell lymphoma.
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