A 60-year-old male develops fever and axillary lymphadenopathy. A lymph node biopsy was performed showing a sheet-like infiltrate of neoplastic cells, some of which are large and shaped like horseshoes. ALK immunohistochemistry is pending. Which of the following statements about this disorder are true?
The cells have a patchy positivity for CD30
|B.||The disease usually involves lymph nodes and affects females more commonly than males|
This entity is a type of T-cell lymphoma
Fluorescent in-situ hybridization (FISH) studies for ALK rearrangement should be performed regardless if immunohistochemistry for ALK is negative
Answer : C This entity is a type of T-cell lymphoma
Epstein Barr virus should have a strong and diffuse positivity for CD30.
ALK-negative anaplastic large cell lymphoma (ALCL) affects males more commonly than females.
ALCL is classified as a type of T-cell lymphoma.
FISH studies for ALK rearrangement are not necessary if ALK immunohistochemistry is negative.