Question
A 55-year-old male presents with a new-onset worsening headache and left arm weakness over the past 2 months. He has a past medical history of primary biliary cirrhosis requiring a liver transplant a few years ago. Magnetic resonance imaging with gadolinium contrast shows a circumscribed solitary homogeneously enhancing periventricular lesion within the right frontal lobe. The lesion is hypointense on T1 and hyperintense on T2 and diffusion-weighted imaging. Corresponding apparent diffusion coefficient values are low. Stereotactic biopsy shows malignant lymphocytes accumulating around blood vessels. His disease is confined to the central nervous system. Which of the following is the most common histological variant of this tumor?
| A. |
High-grade astrocytic cells with angiogenesis and central necrosis |
| B. |
Diffuse large B cells |
| C. |
Anaplastic large T cells |
| D. | Stellate spindle-shaped cells with large eosinophilic cytoplasm |
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