Question
Which of the following is the most likely clinical diagnosis of a patient with peripheral smear findings as shown below?
| A. |
Mantle cell lymphoma
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| B. |
Peripheral T cell lymphoma
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| C. |
Anaplastic large cell lymphoma
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| D. |
Adult T cell leukemia/lymphoma
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Show Answer
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Correct Answer � D
Explanation
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|
Ans. D
The most likely diagnosis is Adult T cell leukemia/lymphoma.
The peripheral smear given above shows tumor cells with multilobulated nuclei (“clover leaf” or “flower” cells).
This is a characteristic of Adult T-Cell Leukemia/Lymphoma.
Adult T-Cell Leukemia/Lymphoma (CD4+)
o Observed in adults infected by human T cell leukemia retrovirus type 1 (HTLV-1)
o Skin lesions, generalized lymphadenopathy, hepatosplenomegaly, peripheral blood lymphocytosis, and hypercalcemia
o Cells with multilobulated nuclei (“clover leaf” or “flower” cells)
o A rapidly progressive disease that is fatal within months to 1 year
Note: Tropical spastic paraparesis is another manifestation of HTLV-1 infection.
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