Question
A patient is on prophylaxis for deep vein thrombosis with subcutaneous Heparin. Which of the following tests can be used to monitor its anticoagulant effect?
| A. |
Prothrombin time
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| B. |
Anti-Factor Xa level
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| C. |
Both A and B
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| D. |
No monitoring is required
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Show Answer
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Correct Answer � B
Explanation
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|
Ans. B
The anticoagulant effect of Heparin can be monitored using activated partial thromboplastin time (aPTT) and Anti-Factor Xa level.
aPTT is prolonged as heparin inhibits intrinsic pathway factors.
Prothrombin time and INR are used to monitor the anticoagulant effect of warfarin (inhibits Vitamin K dependent factor II, VII, IX, X-Factor VII has the shortest half-life).
No monitoring is required with the use of low molecular weight heparin (LMWH) and Fondaparinux.
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