Question
A chronic alcoholic presents with low albumin levels, prolonged PT, and prolonged aPTT. Which of the following clotting factors is most likely to be normal in this patient?
| A. |
Factor II
|
| B. |
Factor VII
|
| C. |
Factor VIII
|
| D. |
Factor IX
|
Show Answer
|
Correct Answer � C
Explanation
|
|
Ans. C
Explanation
Factor VIII is likely to be normal in this patient with alcoholic liver disease affecting the synthetic function of the liver (low albumin and prolonged PT, aPTT)
The liver is the site of production of the following factors:
● fibrinogen (factor I)
● thrombin (factor II)
● V
● VII (shortest half-life, hence PT affected first)
● IX
● X
● XI
Exceptions:
● Factor VIII – produced in endothelial cells
● Factor XIII A-subunit- produced in the bone marrow
Note: Factor VIII levels are used to differentiate between DIC (decreased) and hemorrhagic diathesis of liver disease (normal)
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