Mefloquine plus doxycycline
Ans-c . Intravenous artesunate
Seizure and hypoglycemia indicate complicated falciparum malaria. Any organ system involvement like CNS causing seizures, focal deficits, delirium, hepatobiliary ( hyperbilirubinemia >3), pulmonary ( ALI/pulmonary edema), renal (AKI), hypoglycemia, shock, metabolic acidosis, hyperparasitemia are all included as complicated malaria
Parenteral ( intravenous preferably ) artesunate is the treatment of choice for complicated malaria in both high resistance and low resistance regions to chloroquine.
Uncomplicated falciparum malaria is usually treated with artemisinin combination therapy (ACT) like artemether +lumefantrine in all the regions despite chloroquine resistance.
Uncomplicated vivax malariae and knowlesi are treated with chloroquine
Radical treatment includes anti-relapse drugs like primaquine and tafenoquine, which are given as single doses in falciparum which destroys all the gametocytes in falciparum malaria. In the case of P vivax malaria, 2 weeks of primaquine is given for tissue schizonticidal activity.