Question
DNA Methylation is not associated with:
| A. |
Chromatin remodeling
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| B. |
RNA splicing
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| C. |
Gene silencing
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| D. |
Methyl directed Mismatch Repair
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Show Answer
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Correct Answer � B
Explanation
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Ans: B. RNA Splicing
DNA methylation alters the gene expression pattern in the cells-for example it may cause X-chromosome inactivation, tumor suppressor gene silencing (in cancer cells), suppression of expression of repetitive elements / deleterious elements / viral genes that have been incorporated into the genome of the host over time.
Methylation is most common in CpG islands (a C G rich region, upstream of the promoter region and P signifies phosphodiester bond between them) producing methyl -CpG symmetrically on both strands of DNA.
DNA methylation of adenine at 5′ GATC repair mismatched base pairs. And methylated parental (template) strand is protected from cleavage/digestion by its restriction enzyme
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