Question
The Nigro regimen is used in?
| A. |
Carcinoma of the anal canal
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| B. |
Carcinoma of the colon
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| C. |
Carcinoma of bladder
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| D. |
All of the above
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Show Answer
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Correct Answer � A
Explanation
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|
Ans. A. Carcinoma of anal canal
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In May of 1974, Dr. Norman Nigro at Wayne State University published a series in Diseases of the Colon and Rectum of three patients with anal cancer treated with combined chemotherapy and radiation.
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Dr. Nigro’s protocol of 3000 rads of external beam radiation, a five-day infusion of 5-fluorouricil, and a single injection of mitomycin-C became known as the “Nigro Protocol” and later signified a major advancement in the treatment of anal cancer, and in oncology in general.
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Further refinements would lead to combined chemotherapy and radiation as the primary treatment for anal carcinoma with most patients successfully treated without surgery.
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