The Nigro regimen is used in?
|A.||Carcinoma of the anal canal|
Carcinoma of the colon
Carcinoma of bladder
All of the above
Ans. A. Carcinoma of anal canal
In May of 1974, Dr. Norman Nigro at Wayne State University published a series in Diseases of the Colon and Rectum of three patients with anal cancer treated with combined chemotherapy and radiation.
Dr. Nigro’s protocol of 3000 rads of external beam radiation, a five-day infusion of 5-fluorouricil, and a single injection of mitomycin-C became known as the “Nigro Protocol” and later signified a major advancement in the treatment of anal cancer, and in oncology in general.
Further refinements would lead to combined chemotherapy and radiation as the primary treatment for anal carcinoma with most patients successfully treated without surgery.