Disease with 100% mortality
- Rabies is a viral disease that causes inflammation of the brain in humans and other mammals.Early symptoms can include fever and tingling at the site of exposure. These symptoms are followed by one or more of the following symptoms: violent movements, uncontrolled excitement, fear of water, an inability to move parts of the body, confusion, and loss of consciousness.Once symptoms appear, the result is nearly always death.
- Preventable with vaccines down to ~0% CFR and treatable with PEP but, once the symptoms manifest, the CFR is near 100%. Around 16 documented survivors after symptom onset, all but 3 did not receive any Rabies (specific) treatment at any time before symptom onset. Of those 3, only 1 survived without the use of a therapeutic coma