Which of the following structure is disrupted by Vibrio cholerae?
Correct Ans: C
Ans: C. Zona occludens
vibrio cholerae also produces additional toxins that may contribute to disease, including the zonula occludens toxin (ZOT) that alters intestinal permeability by acting on intestinal epithelial cells tight junctions, and the accessory cholera endotoxin (ACE).”
Vibrio cholerae secretes enterotoxin protein.
Encoded by bacteriophage (CT Xfi resident in V. cholera).
Made up of 1A subunit (composed of 1A1 & 1 A2 peptide joined by disulfide link) & 5B subunits.
Zonula occludens toxin (ZOT):
Alters intestinal permeability by acting on intestinal epithelial cells tight junctions.
Accessory cholera endotoxin (ACE).