Question
33 year old male reported to OPD with c/o recurrent ,flaccid, vesicular eruptions in both axilla .On Nails, Linear white bands are seen. H/p showed Dilapidated brick wall appearance. Its a case of _____with _____ gene defect
| A. |
Hailey Hailey disease,ATP2C1
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| B. |
Darier disease, ATP2A2
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| C. |
Hailey Hailey disease, ATP2A2
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| D. |
Darier disease,ATP2C1
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Show Answer
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Correct Answer � A
Explanation
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Ans (A) Hailey Hailey disease,ATP2C1
Hailey Hailey disease CLUES A male in 3rd decade coming with flaccid blisters and vesicular eruptions in intertriginous areas, with Histopathology showing Dilapidated brick wall appearance points us to DX of Hailey Hailey disease/CHRONIC BENIGN FAMILIAL PEMPHIGUS, gene defect associated with it is in CALCIUM ATPase (ATP2C1)
Nails show Linear white bands
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