Question
What is the main feature of chemotaxis as observed in white blood cells?
| A. |
Increased random movement of neutrophils
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| B. |
Increased adhesiveness to intima
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| C. |
Increased phagocytosis
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| D. |
Unidirectional locomotion of neutrophils
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Show Answer
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Correct Answer � D
Explanation
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|
Ans.D.
Chemotaxis is defined as a unidirectional movement of leukocytes up to a concentration gradient of chemotactic molecules. All granulocytes, monocytes and to a lesser extent lymphocytes respond to chemotactic stimuli with varying rates of speed.
Chemoattractants are exogenous or endogenous. Exogenous agents are bacterial products. Endogenous mediators are:
- Components of complement pathway C5a.
- Products of lipoxygenase pathway LTB4.
- Cytokines particularly those of chemokine families.
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