Neovascular glaucoma-Pathogenesis


Neovascular glaucoma-Pathogenesis


  • Neovascular glaucoma (NVG) is a potentially devastating sequela of serious underlying ocular and/or systemic diseases.
  • The ocular diseases responsible for neovascularization of the iris (NVI) or neovascularization of the angle (NVA) that ultimately lead to NVG are almost always ischemic in nature
  • Under hypoxic conditions, diffusible angiogenic factors, including vascular endothelial growth factor, have been detected in the human and animal retina and vitreous, promoting new vessel growth.
  • Clinically, the three most common conditions responsible for NVG are diabetic retinopathy, central retinal vein occlusion and carotid artery obstructive disease.

Neovascularization:

→Highest O2 consumption in the eye → Retina

Hypoxia

VEGF

Neovascularization
Neovascular glaucoma-Pathogenesis:
Neovascularization

Retina

Vitreous

Iris (Rubeosis Iridis) → Neovascular Iris (NVI)

Neovascular glaucoma

→ Zipper – like closure

→ Secondary angle closure glaucoma

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