Neovascular glaucoma-Pathogenesis
- Neovascular glaucoma (NVG) is a potentially devastating sequela of serious underlying ocular and/or systemic diseases.
- The ocular diseases responsible for neovascularization of the iris (NVI) or neovascularization of the angle (NVA) that ultimately lead to NVG are almost always ischemic in nature
- Under hypoxic conditions, diffusible angiogenic factors, including vascular endothelial growth factor, have been detected in the human and animal retina and vitreous, promoting new vessel growth.
- Clinically, the three most common conditions responsible for NVG are diabetic retinopathy, central retinal vein occlusion and carotid artery obstructive disease.
Neovascularization:
→Highest O2 consumption in the eye → Retina
↓
Hypoxia
↓
VEGF
↓
Neovascularization
Neovascular glaucoma-Pathogenesis:
Neovascularization
↓
Retina
↓
Vitreous
↓
Iris (Rubeosis Iridis) → Neovascular Iris (NVI)
↓
Neovascular glaucoma
→ Zipper – like closure
→ Secondary angle closure glaucoma
