PROTEOGLYCANS

PROTEOGLYCANS

Q. 1 Choose the false statement regarding proteoglycans:

 A Chondroitin sulfate is a Proteoglycan

 B

They hold less amount of water

 C

They are made up of sugar and aminoacids

 D

They carry charge

Q. 1

Choose the false statement regarding proteoglycans:

 A

Chondroitin sulfate is a Proteoglycan

 B

They hold less amount of water

 C

They are made up of sugar and aminoacids

 D

They carry charge

Ans. B

Explanation:

Since the high fixed negative charge density of the proteoglycans allows them tohold enormous amounts of water.
The amount of water depends on the amount of proteoglycans, which decreases with aging.
 
Ref: Harper’s Illustrated Biochemistry 27th Edition, Page 118, 556, 557; Functions of the Proteoglycans By Ciba Foundation Symposium, 2008, Page 143.

 


Q. 2

Which of the following is the major proteoglycan of synovial fluid ‑

 A

Chondroitin sulfate

 B

Dermatan sulfate

 C

Heparan sulfate

 D

Hyaluronic acid

Ans. D

Explanation:

Ans. is ‘d’ i.e., Hyaluronic acid 

   Distribution

Hyaluronic acid 

Synovial fluid (provides viscosity), vitreous humor, loose connective tissue)
Chondroitin sulfate   Cartilage, bone, tendon, ligament, cornea 
Dermatan sulfate   Pliability of skin, and heart valves, wide distribution 
Keratan sulfate  Horny structures like hair, nails, claws, horn, hoofs Also present in cornea 
Heparin Heparan   Mast cells
sulfate   Skin fibroblast, aortic wall


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