Benign Hypertrophy of Prostate (BHP)

BENIGN HYPERTROPHY OF PROSTATE (BHP)

Q. 1 Therapeutic  uses  of  α  –  adrenoreceptor blockers include all of the following except-
 A Hypertension
 B Anxiety
 C Peripheral vascular disease
 D Benign prostatic hypertrophy
Q. 1 Therapeutic  uses  of  α  –  adrenoreceptor blockers include all of the following except-
 A Hypertension
 B Anxiety
 C Peripheral vascular disease
 D Benign prostatic hypertrophy
Ans. B

Explanation:

            

Uses of α -blockers
Uses of β -blockers

•Pheochromocytoma

•Hypertension

•Secondary Shock

•Peripheral vascular disease

•Congestive heart failure

•Benign prostatic hypertrophy

•Migraine

• Hypertension

•Angina

• Cardiac arrhythmias

• Myocardial Infarction

• Pheochromocytoma

• Congestive Heart Failure

 

•Anxiety

• Dissecting aortic aneurysm

• Essential tremor

• Glaucoma

• Hypertrophic cardiomyopathy

• Thyrotoxicosis

• Migraine



 


Q. 2 Alpha 1 blocker used for BHP is:
 A Tamsolusin
 B Prazosin
 C Oxazosin
 D Dolazoline
Q. 2 Alpha 1 blocker used for BHP is:
 A Tamsolusin
 B Prazosin
 C Oxazosin
 D Dolazoline
Ans. A

Explanation:

Tamsolusin


Q. 3 Alpha 1 blocker used for BHP without any effect on blood pressure is:
 A Tamsolusin
 B Terazosin
 C Oxazosin
 D Dolazoline
Q. 3 Alpha 1 blocker used for BHP without any effect on blood pressure is:
 A Tamsolusin
 B Terazosin
 C Oxazosin
 D Dolazoline
Ans. A

Explanation:

Tamsolusin

Quiz In Between


Q. 4

Finasteride is a:

 A

5 alpha reductase inhibitor

 B

PDE inhibitor

 C

Alpha la blocker

 D

Androgen receptor blocker

Q. 4

Finasteride is a:

 A

5 alpha reductase inhibitor

 B

PDE inhibitor

 C

Alpha la blocker

 D

Androgen receptor blocker

Ans. A

Explanation:

Finasteride is a competitive inhibitor of the enzyme 5-alpha reductase which is responsible for the conversion of testosterone into a more active dihydrotestosterone responsible for the androgen action.

When used in benign prostatic hypertrophy, it reduces the prostate size and increased peak urinary flow rate.

It is also used in male pattern baldness and as a palliative treatment in prostatic carcinoma.

Ref: K D Tripathi Textbook of Pharmacology, 5th Edition, Page 272


Q. 5

The following statements regarding finasteride are true, EXCEPT:

 A

It is used in the medical treatment of benign Prostatic hypertrophy (BPH)

 B

Impotence is well documented after its use

 C

It blocks the conversion of dihydrotestosterone to testosterone

 D

It is a 5-a reductase inhibitor

Q. 5

The following statements regarding finasteride are true, EXCEPT:

 A

It is used in the medical treatment of benign Prostatic hypertrophy (BPH)

 B

Impotence is well documented after its use

 C

It blocks the conversion of dihydrotestosterone to testosterone

 D

It is a 5-a reductase inhibitor

Ans. C

Explanation:

Finesteride is a 5-a reductase inhibitor that blocks the formation of dihydrotestosterone from testesterone.

It does not block the reverse reaction i.e. conversion of dihydrotestosterone to testosterone.

Ref: KDT, 5th Edition, Page 272; Goodman Gillman’s The Pharmacological Basis of Therapeutics, Page 1646


Q. 6

The following statements regarding Finasteride are true except –

 A

It is used in the medical treatment of benign prostatic hypertrophy (BPH)

 B

Impotence is well documented after its use

 C

It blocks the conversion of dihydrotestosterone to testosterone

 D

It is a 5a-reductase inhibitor

Q. 6

The following statements regarding Finasteride are true except –

 A

It is used in the medical treatment of benign prostatic hypertrophy (BPH)

 B

Impotence is well documented after its use

 C

It blocks the conversion of dihydrotestosterone to testosterone

 D

It is a 5a-reductase inhibitor

Ans. C

Explanation:

Ans. is ‘c’ i.e., Blocks conversion of dihydrotestosterone to testosterone

Quiz In Between


Q. 7

Finasteride is a –

 A

5-α reductase inhibitor

 B

PDE inhibitor

 C

Alpha blocker

 D

Androgen receptor blocker

Q. 7

Finasteride is a –

 A

5-α reductase inhibitor

 B

PDE inhibitor

 C

Alpha blocker

 D

Androgen receptor blocker

Ans. A

Explanation:

Ans. is ‘a’ i.e., 5-alpha reductase inhibitor


Q. 8

An old man has enlarged prostate. Which of the following may be use to suppress his prostatic growth –

 A

Spironolactone

 B

Ketoconazole

 C

Finasteride

 D

Flutamide

Q. 8

An old man has enlarged prostate. Which of the following may be use to suppress his prostatic growth –

 A

Spironolactone

 B

Ketoconazole

 C

Finasteride

 D

Flutamide

Ans. C

Explanation:

Ans. is ‘c’ i.e., Finasteride

o 5-α reductase inhibitors (finasteride) are used in BPH.


Q. 9

The following statements regarding finasteride are true except

 A

It is used in the medical treatment of Benign prostatic hypertrophy

 B

Impotence is well documented after its use

 C

It blocks the conversion of dihydrotestosterone to testosterone

 D

It is a 5-oc reductase inhibitor

Q. 9

The following statements regarding finasteride are true except

 A

It is used in the medical treatment of Benign prostatic hypertrophy

 B

Impotence is well documented after its use

 C

It blocks the conversion of dihydrotestosterone to testosterone

 D

It is a 5-oc reductase inhibitor

Ans. C

Explanation:

Ans. is ‘c’ i.e. It blocks the conversion of dihydrotestosterone to testosterone 

  • Finasteride is a 5 a-reductase inhibitor which blocks the conversion of testosterone to its more active form dihydrotestosterone
  • Uses
  • BPH – decreases the size of large prostate (> 40 cm3) and can retard disease progression.
  • Male pattern baldness – in patients of male pattern baldness, it promotes hair growth and prevents further hair loss.

Side effects

a)       Impotence: is a well documented although infrequent side effect.

b)       Decreased libido

c)       Decreased volume of ejaculate

d)       Skin rashes

e)       Swelling of lips

Quiz In Between


Q. 10

Which is the earliest symptom of benign hypertrophy of prostate –

 A

Frequency

 B

Haematuria

 C

Incontinence

 D

Strangury

Q. 10

Which is the earliest symptom of benign hypertrophy of prostate –

 A

Frequency

 B

Haematuria

 C

Incontinence

 D

Strangury

Ans. A

Explanation:

Ans. is ‘a’ i.e., Frequency 


Q. 11

An old man is having benign prostatic hypertrophy. Drug useful in such a patient would be:

March 2012

 A

Cyproterone acetate

 B

Danazol

 C

Bicalutamide

 D

Finasteride

Q. 11

An old man is having benign prostatic hypertrophy. Drug useful in such a patient would be:

March 2012

 A

Cyproterone acetate

 B

Danazol

 C

Bicalutamide

 D

Finasteride

Ans. D

Explanation:

Ans: D i.e. Finasteride

Drugs and uses

  • Cyproterone has been clinically tested in precocious puberty in boys, inappropriate sexual behaviour in men, acne and virilisation in women, but is not marketed.
  • Danazol is useful in endometriosis, menorrhagia, fibrocystic breast disease and hereditary angioneurotic edema.
  • Bicalutamide (more potent and longer acting congener of flutamide) is suitable for once daily administration in metastatic carcinoma of prostrate.
  • Treatmentt with finasteride has resulted in decreased prostate size and increased peak urinary flow rate in nearly 50% patients with symptomatic benign hypertrophy of the prostrate (BHP). It is the only drug which can retard disease progression.

Quiz In Between



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