Cholangiocarcinoma

Cholangiocarcinoma


CHOLANGIOCARCINOMA

  • Mucin producing adenocarcinomas that arise from bile ducts
  • Types: intrahepatic, hilar or central (65%) and peripheral (30%)
  • Nodular tumors arising at the bifurcation of the common bile duct are called Klatskin tumors and are often associated with a collapsed gallbladder 

Predisposing factors

  • Primary sclerosing cholangitis
  • Hepatolithiasis
  • Fibropolycystic liver disease
  • Caroli disease (bile duct ectasia)
  • Alcoholic liver disease
  • Choledochal cyst
  • Choledocholithiasis
  • HBV, HCV infection
  • Thorotrast exposure(formerly used in radiography of biliary tree)
  • Opisthorchis viverrini and Clonorchis sinensis infestation 

Premalignant lesions

  • Biliary intraepithelial neoplasia (BiIIN 1, 2,3)
  • Mucinous Cystic Neoplasm
  • Intraductal Papillary Biliary Neoplasia 

Clinical features, diagnosis and treatment

  • Typically presents with painless jaundice often with pruritis and weight loss
  • CEA, CA 19-9, and CA-125 are often elevated in CCC patients and are useful for following response to therapy
Exam Question
 
  • Mucin producing adenocarcinomas that arise from bile ducts
  • Types: intrahepatic, hilar or central (65%) and peripheral (30%)
  • Nodular tumors arising at the bifurcation of the common bile duct are called Klatskin tumors and are often associated with a collapsed gallbladder
Don’t Forget to Solve all the previous Year Question asked on Cholangiocarcinoma

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