Fatty Liver

Fatty liver

Q. 1

Accumulation and deposition of which of the following result in fatty liver?

 A

Triglycerides

 B

Lipoprotiens

 C

LDL

 D

VLDL

Q. 1

Accumulation and deposition of which of the following result in fatty liver?

 A

Triglycerides

 B

Lipoprotiens

 C

LDL

 D

VLDL

Ans. A

Explanation:

Fatty liver refers to the deposition of excess triglycerides in the liver cells.

Causes of fatty liver are:
  • Increased mobilisation of nonesterified fatty acids from adipose tissue
  • Increased synthesis of fatty acid from glucose
  • Decreased secretion of VLDL
  • Decreased rate of oxidation of fat by hepatic cells
 
Ref: Textbook of Biochemistry By D M Vasudevan, 3rd Edition, Page 130

 


Q. 2

All of the following statements about Non Alcoholic Fatty Liver disease are true, except:

 A

Common in Diabetics

 B

Clofibrate provides effective treatment

 C

Commonest cause of cryptogenic cirihosis

 D

Associated with elevated transminases

Q. 2

All of the following statements about Non Alcoholic Fatty Liver disease are true, except:

 A

Common in Diabetics

 B

Clofibrate provides effective treatment

 C

Commonest cause of cryptogenic cirihosis

 D

Associated with elevated transminases

Ans. B

Explanation:

Answer is B (Clofibrate provides effective treatment):

Non Alcoholic fatty Liver Disease (NAFLD) is common in Diabetics Commonest Associations of NAFLD / NASH (Robbins)

  • Obesity
  • Dyslipidemia
  • Hyperinsulinemia (Insulin resistance is a charachteristic.feature2)
  • Diabetes

NAFLD is believed to be the commonest cause of cryptogenic cirrhosis

NAFL is now considered the most common cause of ‘ctyptogenic cirrhosis’ – Robbins 7th/908 Spectrum of NAFLD

  • Simple steatosis (Early)
  • Steatohepatitis (NASH) : Non Alcoholic Steatohepatitis) (Intermediate)
  • Fibrosis and cirrhosis (Advanced)

NAFLD is associated with elevated transminases (transaminitis)

‘Most patients with NAFLD come to medical attention as a result of incidentally elevated liver enzymes’ – Harrison

  • ALT > AST
  • Aminotransferases are usually only mildly elevated 2 times normal

Q. 3

Fatty liver is due to accumulation of ‑

 A

Triglycerides

 B

LDL

 C

Lipoprotein a

 D

VLDL

Q. 3

Fatty liver is due to accumulation of ‑

 A

Triglycerides

 B

LDL

 C

Lipoprotein a

 D

VLDL

Ans. A

Explanation:

Ans. is ‘a’ i.e., Triglycerides

Fatty change (Steatosis) :‑

  • The term steatosis (fatty change) describe abnormal accumlation of triglyceride within parenchymal cells.

Quiz In Between



Leave a Reply

Free Mini Course on Stomach

Mini Course – Stomach

22 High Yield Topics in Stomach

in Just 2 Hours

Submission received, thank you!

Close Window
%d bloggers like this:
Malcare WordPress Security