Laxatives

LAXATIVES

Q. 1

Laxative abuse is associated with:

 A

Hypokalemia

 B

Hypomagnesemia

 C

Hypoglycemia

 D

Colonic spacticity

Q. 1

Laxative abuse is associated with:

 A

Hypokalemia

 B

Hypomagnesemia

 C

Hypoglycemia

 D

Colonic spacticity

Ans. A

Explanation:

Ans. a. Hypokalemia

“Noninfectious gastrointestinal processes such as celiac disease, ileostomy, villous adenomas, VIPomas, and chronic laxative abuse also can cause significant hypokalemia.”- Harrison 18/e p351

“Diarrhea due to laxative abuse is an occasional cause of hypokalemia in the adolescent or adult

Non-Renal Loss of Potassium

  • The loss of IC in sweat is typically low except under extremes of physical exertion.
  • Direct gastric losses of IC due to vomiting or nasogastric suctioning are also minimal; however, the ensuing hypochloremic alkalosis results in persistent kaliuresis due to secondary hyperaldosteronism and bicarbonaturia, i.e., a renal loss of Kt
  • Intestinal loss of IC- due to diarrhea is a globally important cause of hypokalemiaQ in light of the worldwide prevalence of diarrheal disease.
  • Noninfectious gastrointestinal processes such as celiac disease, ileostomy, villous adenomas, VIPomas, and chronic laxative abuse also can cause significant hypokalemiaQ
  • Colonic pseudo-obstruction (Ogilvie’s syndrome) can lead to hypokalemia from secretory diarrhea with an abnormally high potassium content caused by a marked activation of colonic IC secretionQ.

Q. 2

Lubiprostone is ‑

 A

New anticholinergic antidiarrhoeal

 B

Serotonin agonist

 C

New drug to treat peptic ulcer

 D

To treat irritable bowel syndrome

Q. 2

Lubiprostone is ‑

 A

New anticholinergic antidiarrhoeal

 B

Serotonin agonist

 C

New drug to treat peptic ulcer

 D

To treat irritable bowel syndrome

Ans. D

Explanation:

Ans. is ‘d’ i.e., To treat irritable bowel syndrome

  • Lubiprostone is a PG analogue (EP4 receptor agonist), developed recently, represents a new strategy in the treatment of constipating-predominant IBS and chronic constipation.
  • It acts by ‑
  1. Stimulating CI- channel opening in the intestine.
  2. Increasing liquid secretion in gut.
  3. Decreasing transit time.

Quiz In Between



This site uses Akismet to reduce spam. Learn how your comment data is processed.

%d bloggers like this:
Malcare WordPress Security