Laxatives

LAXATIVES

Q. 1

Laxative abuse is associated with:

 A

Hypokalemia

 B

Hypomagnesemia

 C

Hypoglycemia

 D

Colonic spacticity

Q. 1

Laxative abuse is associated with:

 A

Hypokalemia

 B

Hypomagnesemia

 C

Hypoglycemia

 D

Colonic spacticity

Ans. A

Explanation:

Ans. a. Hypokalemia

“Noninfectious gastrointestinal processes such as celiac disease, ileostomy, villous adenomas, VIPomas, and chronic laxative abuse also can cause significant hypokalemia.”- Harrison 18/e p351

“Diarrhea due to laxative abuse is an occasional cause of hypokalemia in the adolescent or adult

Non-Renal Loss of Potassium

  • The loss of IC in sweat is typically low except under extremes of physical exertion.
  • Direct gastric losses of IC due to vomiting or nasogastric suctioning are also minimal; however, the ensuing hypochloremic alkalosis results in persistent kaliuresis due to secondary hyperaldosteronism and bicarbonaturia, i.e., a renal loss of Kt
  • Intestinal loss of IC- due to diarrhea is a globally important cause of hypokalemiaQ in light of the worldwide prevalence of diarrheal disease.
  • Noninfectious gastrointestinal processes such as celiac disease, ileostomy, villous adenomas, VIPomas, and chronic laxative abuse also can cause significant hypokalemiaQ
  • Colonic pseudo-obstruction (Ogilvie’s syndrome) can lead to hypokalemia from secretory diarrhea with an abnormally high potassium content caused by a marked activation of colonic IC secretionQ.

Q. 2

Lubiprostone is ‑

 A

New anticholinergic antidiarrhoeal

 B

Serotonin agonist

 C

New drug to treat peptic ulcer

 D

To treat irritable bowel syndrome

Q. 2

Lubiprostone is ‑

 A

New anticholinergic antidiarrhoeal

 B

Serotonin agonist

 C

New drug to treat peptic ulcer

 D

To treat irritable bowel syndrome

Ans. D

Explanation:

Ans. is ‘d’ i.e., To treat irritable bowel syndrome

  • Lubiprostone is a PG analogue (EP4 receptor agonist), developed recently, represents a new strategy in the treatment of constipating-predominant IBS and chronic constipation.
  • It acts by ‑
  1. Stimulating CI- channel opening in the intestine.
  2. Increasing liquid secretion in gut.
  3. Decreasing transit time.

Quiz In Between



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