Malate Shuttle

Malate Shuttle

Q. 1

Which is the following is associated with the malate shuttle?

 A

Glycolysis

 B

Gluconeogenesis

 C

Glycogenolysis

 D

Ketone body synthesis

Q. 1

Which is the following is associated with the malate shuttle?

 A

Glycolysis

 B

Gluconeogenesis

 C

Glycogenolysis

 D

Ketone body synthesis

Ans. A

Explanation:

Malate shuttleis a biochemical system for translocating electrons produced during glycolysis across the semi permeable inner membrane of the mitochondrion for oxidative phosphorylation. These electrons enter the electron transport chain of the mitochondria via

reduction equivalents to generate ATP.
 
The NADPH produced in glycolysis is transported into the mitochondria with the help of Malate shuttle to liberate 3 ATP molecules.

Q. 2

Malate shuttle is important in –

 A

Glycogenolysis

 B

Glycolysis

 C

Gluconeogenesis

 D

HMP shunt

Q. 2

Malate shuttle is important in –

 A

Glycogenolysis

 B

Glycolysis

 C

Gluconeogenesis

 D

HMP shunt

Ans. B

Explanation:

B i.e. Glycolysis

Mallate shuttle is a system by which reducing equivalents (NADH) produced in glycolysisQ are transferred from cytosol to mitochondria to yield energy.

NADH produced in the glycolysisQ, is extramitochondrial where as the electron transport chain, where NADH has to be oxidized to NAD+ is in the mitochondria (Oxidation of 1 NADH yields 3 ATP/2.5 ATP). NADH is impermeable to mitochondrial membrane, so to enable transfer of NADH inside mitochondria Shuttle system is utilized.

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