Rabies Virus

Rabies Virus

Q. 1

Which of the following sites in the brain is a favored locations for ischemic damage, rabies virus infestation, and toxic damage resulting from alcohol?

 A

Nucleus basalis of Meynert cell

 B

Purkinje cells of cerebellum

 C

Third, fifth, and sixth cortical layers of neurons in cerebral hemispheric grey matter

 D

Ammon’s horn of the hippocampal gyrus

Q. 1

Which of the following sites in the brain is a favored locations for ischemic damage, rabies virus infestation, and toxic damage resulting from alcohol?

 A

Nucleus basalis of Meynert cell

 B

Purkinje cells of cerebellum

 C

Third, fifth, and sixth cortical layers of neurons in cerebral hemispheric grey matter

 D

Ammon’s horn of the hippocampal gyrus

Ans. B

Explanation:

The site in the brain that is a favored location for ischemic damage, rabies virus infestation, and toxic damage resulting from alcohol is the Purkinje cells in the cerebellum.

In chronic ischemia, the Purkinje cells undergo apoptosis (individual cell necrosis) and assume a shrunken, deeply eosinophilic cytoplasm with fading out of the nucleus (red neuron). The eosinophilic Negri inclusion body of rabies is located in the cytoplasm of the Purkinje cells. Alcohol has a direct toxic effect on Purkinje cells, resulting in cerebellar atrophy. 

The nucleus basalis of Meynert is associated with neuronal loss in Alzheimer disease. 


Q. 2

Which of the following statements is TRUE about Rabies Virus:

 A

It is double stranded RNA virus

 B

Contains a DNA-dependent RNA polymerase

 C

Negative sense RNA Genome

 D

Affects motor neurons

Q. 2

Which of the following statements is TRUE about Rabies Virus:

 A

It is double stranded RNA virus

 B

Contains a DNA-dependent RNA polymerase

 C

Negative sense RNA Genome

 D

Affects motor neurons

Ans. C

Explanation:

The Rabies virus belongs to the Rhabdoviridae family, and is the prototypic member of the genus lyssavirus.
It has a single-stranded, non-segmented, negative-sense RNA genome.

The helical nucleocapsid is composed of a single-stranded negative-sense RNA genome and an RNA-dependent RNA polymerase enclosed in a matrix protein covered by a lipid bilayer envelope containing knob-like glycoprotein.

Note – Negative-sense RNA virus replicates in the cytoplasm

 
Ref: Microbiology By Jawetz, 20th Edition, Page 482 ; Rabies By Alan C. Jackson, William H. Wunner, 2007, Page 24

Q. 3

All are true regarding Rabies virus, except?

 A

Single Stranded RNA virus

 B

Linear

 C

Negative sense

 D

Space vehicle shaped

Q. 3

All are true regarding Rabies virus, except?

 A

Single Stranded RNA virus

 B

Linear

 C

Negative sense

 D

Space vehicle shaped

Ans. D

Explanation:

It is a bullet shaped virus with a single serotype. It is detected by immunofluoresence. 

The rabies virus is a neurotropic virus.

These viruses areenveloped and have a single stranded RNA genome with negative-sense. All transcription and replication events take place in the cytoplasm inside a specialized “virus factory“, the Negri body.


Q. 4

Speed of rabies virus in axon is?

 A

1 mm per hour

 B

3 mm per hour

 C

5 mm per hour

 D

7 mm per hour

Q. 4

Speed of rabies virus in axon is?

 A

1 mm per hour

 B

3 mm per hour

 C

5 mm per hour

 D

7 mm per hour

Ans. B

Explanation:

Ans. is ‘b’ i.e., 3 mm per hour


Q. 5

Street rabies virus cause ‑

 A

Natural rabies

 B

Loboratory passage in rabbit

 C

Fatal encephalitis in 6 days

 D

Negri bodies not seen

Q. 5

Street rabies virus cause ‑

 A

Natural rabies

 B

Loboratory passage in rabbit

 C

Fatal encephalitis in 6 days

 D

Negri bodies not seen

Ans. A

Explanation:

Ans. is ‘a’ i.e., Natural rabies


Q. 6

Rabies virus is inactivated by –        

 A

Phenol

 B

UV radiation

 C

BPL

 D

All

Q. 6

Rabies virus is inactivated by –        

 A

Phenol

 B

UV radiation

 C

BPL

 D

All

Ans. D

Explanation:

Ans. is ‘d’ i.e., All

  • Rabies virus is sensitive to

-Ethanol                                                     – Soap

– Iodine Preparations                                 – Detergents

– Quaternary ammonium Compound – Lipid Solvents such as ether, chloroform and acetone

  • Rabies virus is inactivated by

-Phenol                                                       – UV irradiation

– Formalin                                                   – Sun Light

Beta propiolactone (BPL)                              – Thermal inactivation (one hour at 500 C and 5 min at 60°C)


Q. 7

True about Rabies virus is –

 A

Rabies is diagnosed by immunofluorescence

 B

Rabies causes life long immunity

 C

Rabies has various strains of viruses

 D

Rabies vaccine is always live attenuated

Q. 7

True about Rabies virus is –

 A

Rabies is diagnosed by immunofluorescence

 B

Rabies causes life long immunity

 C

Rabies has various strains of viruses

 D

Rabies vaccine is always live attenuated

Ans. A

Explanation:

Ans. is ‘a’ i.e., Rabies is diagnosed by immunofluorescence

.  Diagnosis of rabies is usually made by the detection of rabies virus antigens by immunofluorescence.

.  Rabies does not cause life long immunity, in fact rabies infection cause death of all patients.

.  Rabies virus is of single serotype only.

.  Rabies Vaccines are killed inactivated vaccines


Q. 8

The following statments are true for negri bodies except –

 A

They are pathognomic of rabies

 B

They are found in the brain

 C

They are cytoplasmic inclusion bodies

 D

They do not contain rabies virus antigen

Q. 8

The following statments are true for negri bodies except –

 A

They are pathognomic of rabies

 B

They are found in the brain

 C

They are cytoplasmic inclusion bodies

 D

They do not contain rabies virus antigen

Ans. D

Explanation:

Ans. is ‘d’ i.e., They do not contain rabies virus antigen


Q. 9

Rabies virus –

 A

Can be isolated from the blood of infected patients

 B

Has multiple antigenic types

 C

Can be transmitted by a dog 4 weeks before the dog becomes noticeably ill

 D

Produce infection that is almost fatal to

Q. 9

Rabies virus –

 A

Can be isolated from the blood of infected patients

 B

Has multiple antigenic types

 C

Can be transmitted by a dog 4 weeks before the dog becomes noticeably ill

 D

Produce infection that is almost fatal to

Ans. D

Explanation:

Ans. is ‘d’ i.e., Produce infection that is almost fatal to humans

Rabies may present as                                                                                                     

.    Predominantly encephalitic disease – furious rabies

.    Paralytic illness – dumb rabies

In humans, about two – thirds suffer the encephalitic form and die within 7 days, the rest initially present as paralytic then develop encephalitis, and death may not occur for 2-3 weeks. Survival is exceedingly rare. About other options

.  There is no clinically significant viremia, so virus can not be isolated from the blood.

.  There are two types of strains –> Street virus and fixed virus, but they are antigenically similar.

.   Rabies virus can be transmitted from dog to man 3-4 days before the onset of clinical symptoms (not 4 weeks)


Q. 10

The following statments are true for these cells which is presented by arrow except 

 A

They are pathognomic of rabies

 B

They are found in the brain

 C

They are cytoplasmic inclusion bodies

 D

They do not contain rabies virus antigen

Q. 10

The following statments are true for these cells which is presented by arrow except 

 A

They are pathognomic of rabies

 B

They are found in the brain

 C

They are cytoplasmic inclusion bodies

 D

They do not contain rabies virus antigen

Ans. D

Explanation:

These cells are Negri bodies

Ans. is ‘d’ i.e., They do not contain rabies virus antigen



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