TOPOISOMERASE INHIBITORS
Etoposide acts by –
| A |
Inhibition of dihydrofolate |
|
| B |
Inhibition of topoisomerase |
|
| C |
Inhibition of purine synthesis |
|
| D |
Inhibition of protein synthesis |
Etoposide acts by –
| A |
Inhibition of dihydrofolate |
|
| B |
Inhibition of topoisomerase |
|
| C |
Inhibition of purine synthesis |
|
| D |
Inhibition of protein synthesis |
Ans. is ‘b’ i.e., Inhibition of topoisomerase
o Etoposide and teniposide are natural anticancer drugs.
o They act by inhibiting topoisomerase II that leads to DNA strand breakage.
Which one of the following drugs is `Topoisomerase 1 inhibitor ?
| A |
Doxorubicin |
|
| B |
Irinotecan |
|
| C |
Etoposide |
|
| D |
Vincristine |
Which one of the following drugs is `Topoisomerase 1 inhibitor ?
| A |
Doxorubicin |
|
| B |
Irinotecan |
|
| C |
Etoposide |
|
| D |
Vincristine |
Ans. is ‘b’ i.e., Irinotecan
- Topoisomerase I inhibitors –> camptothecans (Irinotecan, tropotecan).
Topoisomerase II inhibitors Anthracyclines (doxorubicin, daunorubicin) and Epipodophyllotoxin (Etoposid, teniposide).
