Topoisomerase Inhibitors

TOPOISOMERASE INHIBITORS

Q. 1

Etoposide acts by –

 A

Inhibition of dihydrofolate

 B

Inhibition of topoisomerase

 C

Inhibition of purine synthesis

 D

Inhibition of protein synthesis

Q. 1

Etoposide acts by –

 A

Inhibition of dihydrofolate

 B

Inhibition of topoisomerase

 C

Inhibition of purine synthesis

 D

Inhibition of protein synthesis

Ans. B

Explanation:

Ans. is ‘b’ i.e., Inhibition of topoisomerase

o Etoposide and teniposide are natural anticancer drugs.

o They act by inhibiting topoisomerase II that leads to DNA strand breakage.


Q. 2

Which one of the following drugs is `Topoisomerase 1 inhibitor ?

 A

Doxorubicin

 B

Irinotecan

 C

Etoposide

 D

Vincristine

Q. 2

Which one of the following drugs is `Topoisomerase 1 inhibitor ?

 A

Doxorubicin

 B

Irinotecan

 C

Etoposide

 D

Vincristine

Ans. B

Explanation:

Ans. is ‘b’ i.e., Irinotecan

  • Topoisomerase I inhibitors –> camptothecans (Irinotecan, tropotecan).

Topoisomerase II inhibitors   Anthracyclines (doxorubicin, daunorubicin) and Epipodophyllotoxin (Etoposid, teniposide).

Quiz In Between



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