Retroperitoneal fibrosis

Retroperitoneal fibrosis

Q. 1

Most common organ involved in retroperitoneal fibrosis is –

 A Aorta

 B Ureter

 C

Inferior vena cava

 D

Sympathetic nerve plexus

Q. 1

Most common organ involved in retroperitoneal fibrosis is –

 A

Aorta

 B

Ureter

 C

Inferior vena cava

 D

Sympathetic nerve plexus

Ans. B

Explanation:

Ans. is `b’ i.e., Ureter

  • Retroperitoneal fibrosis (RPF) is characterized by the development of extensive fibrosis throughout the retroperitoneum, typically centered over the anterior surface of the fourth and fifth lumbar vertebrae and resulting in entrapment and obstruction of retroperitoneal structures, notably the ureters.

Clinical Features- 

  • Dull, poorly localized, noncolicky pain in the flank, back, scrotum, or lower abdomen.
  • Fever
  • Lower-extremity edema
  • Phlebitis
  • Deep venous thrombosis
  • Weight loss, nausea, vomiting, anorexia, and malaise: Uncommon presentations

Q. 2 Retroperitoneal fibrosis is seen with which 5HT1 and 5HT2 receptor antagonist:  

March 2013 (d)

 A Ketanserin

 B

Cyproheptadine

 C

Methysergide

 D

All of the above

Ans. C

Explanation:

Ans. C i.e. Methysergide

Important side effects of drugs

  • Drug deposited in retina: Chloroquine
  • Drug deposited in muscle: Digoxin
  • Drugs causing hepatitis: Halothane, Rifampin, INH, pyrazinamide
  • Drugs causing intrahepatic cholestasis: Phenothiazines, TCA
  • Hepatotoxins: CC14, Paracetamol
  • Bleomycin and pulmonary changes: Pulmonary fibrosis (stimulation of alveolar macrophages)
  • Drugs causing pulmonary fibrosis: Bleomycin, Busulfan
  • Cardiotoxic drugs: Doxarubicin, Daunorubicin
  • Drugs causing osteoporosis: Glucocorticoids, Heparin
  • Drugs with low safety margin: Lithium, Aminoglycosides, Digoxin
  • Drugs causing hyperuricemia: Pyrazinamide, Ethambutol
  • Drugs causing hirsutism: Minoxidil, Phenytoin
  • Drugs causing extra-pyramidal side effects: Haloperidol, Levodopa
  • In Glucose-6-phosphate deficiency, haemolysis is caused by: Dapsone,

–        Primaquine,

–        Sulfonamides etc.



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