Tag: hCG

Levels of hCG


Levels of hCG


↑ hCG:

  • Multifetal pregnancy
  • Gestational Trophoblastic disease
  • Down syndrome
  • Under estimated gestational age
  • Erythroblastosis fetalis

↓ hCG:

  • Abortion
  • Trisomy other than Down syndrome
  • Ectopic pregnancy

Hormonal functions of placenta


Hormonal functions of placenta


→ Important hormones synthesized by placenta are:

  • Progesterone
  • Estrogen
  • Human placental lactogen (HPL)
  • Human chorionic gonadotropin (hCG)

→Others are:

  • Human chorionic thyrotropin
  • Pregnancy specific β, glycoprotein
  • Pregnancy associated plasma protein A (PAPP-A)

Functions of hCG


Functions of hCG


→ Maintains corpus luteum of pregnancy.

→ It simulates LH and provides the first stimulus for release of testosterone from fetal testis.

→ It has immunosuppressive action and prevents rejection of fetus.

→ It stimulates maternal thyroid gland.

→ It is used for diagnostic test like triple test for down syndrome.

Clinical Titre of hCG


Clinical Titre of hCG


→ The titer of hCG at which gestational sac should be visible on TVS in case of intrauterine pregnancy = 1500 IU/L

Case 1: If the UPT is positive and HCG titer is =1000 IU/L and on TVS gestational sac is not visible. Then it can be a case of early intrauterine pregnancy, ectopic pregnancy or abortion.

In such cases repeat the test after 24 hours.

  • If after 24 hrs. values double than confirm intrauterine pregnancy,
  • If reduced than abortion.

→ The titer of hCG at which gestational sac should be visible on TAS in case of intrauterine pregnancy =6000 IU/L – 6500 IU/L

Case 2: If the UPT is positive and HCGl titer is >1500IU/L and on TVS gestational sac is not visible (Normally in Intrauterine Pregnancy It Is Visible) then it is a case of ectopic pregnancy

  • If value increases but does not double, it is a case of ectopic pregnancy
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