Most serious complication of the condition shown in the picture below is ?
C. Otitis media.
Correct Answer » B
The disorder shown in the picture above represents measels.
Measles is a highly communicable acute disease. It is also known as rubeola and is marked by prodromal fever, cough, coryza, conjunctivitis, and pathognomonic enanthem (i.e., Koplik spots), followed by an erythematous maculopapular rash on the third to seventh day.
Infection confers life-long immunity.
A generalized immunosuppression that follows acute measles frequently predisposes patients to bacterial otitis media and bronchopneumonia.
In approximately 0.1% of cases, measles causes acute meningo-encephalitis,which is the most serious complication. Subacute sclerosing panencephalitis (SSPE) is a rare chronic degenerative disease that occurs several years after measles infection.
A patient presented with fever, night sweats and weight loss. Clinical examination revealed painless lymphadenopathy. Microscopy shows these cells. Most likely condition is:
B. Chronic lymphocytic leukemia
C. Hodgkin’s lymphoma
D. Secondary TB
Correct Answer » C
These cells are Reed Sternberg cells
Ans: C i.e. Hodgkins lymphoma
Reed–Sternberg cells (also known as lacunar histiocytes )
These are different giant cells found with light microscopy in biopsies from individuals with Hodgkin’s lymphoma
They are usually derived from B lymphocytes, classically considered crippled germinal center B cells, meaning they have not undergone hypermutation to express their antibody. Seen against a sea of B cells, they give the tissue a moth-eaten appearance.
Classification of Hodgkin’s is based on the reactive cell mixture. Immunomarkers are used (e.g., CD15 and CD30).
Reed–Sternberg cells are large 30–50 microns and are either multinucleated or have a bilobed nucleus with prominent eosinophilic inclusion-like nucleoli (thus resembling an “owl’s eye” appearance).
Reed–Sternberg cells are CD30 and CD15 positive, usually negative for CD20 and CD45.
The presence of these cells is necessary in the diagnosis of Hodgkin’s lymphoma – the absence of Reed–Sternberg cells has very high negative predictive value.
They can also be found in reactive lymphadenopathy (such as infectious mononucleosis immunoblasts which are RS like in appearance, carbamazepine associated lymphadenopathy) and very rarely in other types of non-Hodgkin lymphomas. Anaplastic large cell lymphoma may show RS like cells also.