HLA complex in man is located on DNA structure (photograph) numbered ?
HLA complex in man is located on chromosome 6.
Human leukocyte antigen (HLA) complex
- It is a gene complex encoding the major histocompatibility complex (MHC) proteins in humans.
- These cell-surface proteins are responsible for the regulation of the immune system in humans.
- The HLA gene complex resides on a within chromosome 6.
- HLAs corresponding to MHC class I (A, B, and C) present peptides from inside the cell. For example, if the cell is infected by a virus, the HLA system brings fragments of the virus to the surface of the cell so that the cell can be destroyed by the immune system.
- HLAs corresponding to MHC class II (DP, DM, DOA, DOB, DQ, and DR) present antigens from outside of the cell to T-lymphocytes.
- HLAs corresponding to MHC class III encode components of the complement system.
- They are the major cause of organ transplant rejections.