OPIOID ANTAGONIST Q. 1 A 56-year-old man undergoes a left upper lobectomy. An epidural catheter is inserted for postoperative pain relief. Ninety minutes after the first dose of epidural morphine, the patient complains of itching and becomes increasingly somnolent. Blood gas measurement reveals the following: pH 7.24; PaCO2 58; Pa02 100; HCO3:28 Initial therapy should […]
OPIOID ANTAGONIST OPIOID ANTAGONISTS Drugs included: Naloxone, Naltrexone & Nalmefene: Potent µ-receptor antagonist Significant blocking action at κ and δ-receptors. Methylnaltrexone, Alvimopan & Naloxegol: Peripheral opioid antagonists Individual drugs: Naloxone: Ineffective orally & given parenterally. Very short acting drug. Nalmefene: Given parenterally. Longer half-life. Naltrexone: Orally-effective. Long-acting. Actions of opioid antagonist: Mainly reverses opioid effects on
