Tag: PIH

Drugs to prevent Pregnancy Induced hypertension

Drugs to prevent Pregnancy Induced hypertension

  1. Best- Aspirin (↓ Thromboxane A2)

  2. Dose of Asprin-50-150 mg/day @ 12-28 weeks (if pt. develops PIH then continue throughout pregnancy

  3. Heparin & Aspirin

  4. Ca2+ supplementation if it is ↓

  5. Regular exercise

→ Following has No role in preventing PIH: –

  1. Bed Rest

  2. Diet Salt restriction

  3. Supplementation of Fish oil

  4. Supplementation of antioxidants

  5. Low dose Heparin alone

  6. Supplementation of Vitamin C, D and E

Antiphospholipid antibody syndrome

Antiphospholipid antibody syndrome

• APLA syndrome can lead to thrombosis in vessels. Depending upon which vessels get thrombosed we will get the manifestation like if cerebral vessel get thrombosed manifestation of stroke can be seen. It can even lead to thrombosis in placental blood vessels.

  •  Based on this size of placenta will decrease and there will be placental insufficiency.
  • Abortion can happen in first trimester due to APLA but it generally causes abortion in second trimester (M/C).
  •  Even if there is 1 abortion due to APLA but for first trimester we need 3 abortion to say it is caused due to APLA.

Antihypertensives for chronic hypertension in pregnancy

Antihypertensives for chronic hypertension in pregnancy

For PIH/PE-1st choice- Labetalol

Chronic HT in Pregnancy-Labetalol or α-Methyl Dopa

HT Crisis-I/V Labetalol, I/V Hydralazine

Safe Antihypertensive:

  • Labetalol
  • Alpha-methyldopa (safest)
  • Nitroglycerine
  • Calcium channel blockers – nifedipine
  • Hydralazine
  • Sodium nitroprusside (last resort)
  • Beta Blockers

Contraindicated during pregnancy:

  • ACE inhibitors – like enalapril, captopril
  • Angiotensin receptor blockers-Losartan
  • Diuretics
  • Atenolol
  • Diazoxide

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