Rifampicin

Rifampicin RIFAMPICIN INTRODUCTION: Semisynthetic derivative of rifamycin B obtained from Streptomyces mediterranei. Included in macrolide antibiotic group. Eventually, 7 types were developed they are Rifamycin A, B, C, D, E, S, SV. MECHANISM OF ACTION: Bactericidal at 0.005-0.2micrograms/ml. Inhibits gram-positive bacteria. Works by binding non-covalently to β-subunits of DNA-dependent RNA polymerase (DDRP) —> Inhibiting RNA synthesis initiation. DNA-dependent RNA polymerases in eukaryotic cells are unaffected. Because of […]