Tag: WOUND HEALING- Complications

WOUND HEALING- Complications, Factors & Strength

WOUND HEALING- Complications, Factors & Strength

Q. 1

Wound healing is affected by:

 A

Age

 B

Nutrition

 C

Dryness or wetness of wound

 D

a and b

Q. 1

Wound healing is affected by:

 A

Age

 B

Nutrition

 C

Dryness or wetness of wound

 D

a and b

Ans. D

Explanation:

Ans. is ‘ a ‘ , ‘ b ‘

Factors that adversely affect wound healing

•   Local

•   Abnormal blood supply (ischemia due to arterial disease or impaired venous drainage, e.g.

arteriosclerosis, varicose veins)

•   Infection

•   Presence of foreign material, necrotic tissue or excessive blood (hematoma)

•   Movement in injured area

•   Tension in injured area

•   Irradiation (decreases the viability of cells)

•   Denervation

•   Systemic

•   Advanced age

•   Failure of collagen synthesis d/t

– vitamin C deficiency

– protein deficiency

– zinc deficiency

– Ehlers-Danlos syndrome (disorder characterized by defective collagen formation,

hyperextensible joints, fragile tissues and impaired wound healing)

•     Diabetes mellitus

•     Corticosteroid excess (administration of exogenous corticosteroids or Cushing’s syndrome)

•     Malnutrition

•     Anemia

•  Obesity

•   Drugs (steroids, cytotoxic medication, intensive antibiotic therapy)

•   Genetic disorders (osteogenesis imperfecta, Ehler-Danlos syndrome, Marfan syndrome)

•   Systemic infection

•   Malignant disease

•  Temperature

•  Trauma, hypovolemia and hypoxia

•   Uremia

•   Bleeding disorder


Q. 2

The Vitamin which has inhibitory effect on wound healing is –

 A

Vitamin -A

 B

Vitamin – E

 C

Vitamin -C

 D

Vitamin B-complex

Q. 2

The Vitamin which has inhibitory effect on wound healing is –

 A

Vitamin -A

 B

Vitamin – E

 C

Vitamin -C

 D

Vitamin B-complex

Ans. B

Explanation:

Ans. is ‘b’ i.e., Vitamin-E. 


Q. 3

Fibroblasts in healing wound are derived from –

 A

Local mesenchyme

 B

Epithelium

 C

Endothelium

 D

Vascular fibrosis

Q. 3

Fibroblasts in healing wound are derived from –

 A

Local mesenchyme

 B

Epithelium

 C

Endothelium

 D

Vascular fibrosis

Ans. A

Explanation:

Ans. is ‘a’ i.e. Local mesenchyme 

Fibroblasts are specialized cells that differentiate from resting mesenchyme cells in connective tissue. They do not arrive in the wound cleft by diapedesis from circulating cells.

Quiz In Between


Q. 4

A patient of total parenteral nutrition develops delayed wound healing, loss of taste, deficient immunity and diarrhea. Most probably it could be due to deficiency of:          September 2008

 A

Selenium

 B

Copper

 C

Zinc

 D

Iron

Q. 4

A patient of total parenteral nutrition develops delayed wound healing, loss of taste, deficient immunity and diarrhea. Most probably it could be due to deficiency of:          September 2008

 A

Selenium

 B

Copper

 C

Zinc

 D

Iron

Ans. C

Explanation:

Ans. C: Zinc

Symptoms of Zinc Deficiency

  • Poor Immune system
  • Weight loss
  • Intercurrent infections
  • Hypogonadism in males
  • Lack of sexual development in females
  • Growth retardation
  • Dwarfism
  • Delayed puberty in adolescents
  • Rough skin
  • Poor appetite
  • Mental lethargy
  • Delayed wound healing
  • Short stature
  • Diarrhea

Congenital abnormalities causing zinc deficiency may lead to a disease called acrodermatitis enteropathica.


Q. 5

Most important vitamin, which promotes wound healing ?

 A

Vitamin C

 B

Vitamin D

 C

Vitamin A

 D

Niacin

Q. 5

Most important vitamin, which promotes wound healing ?

 A

Vitamin C

 B

Vitamin D

 C

Vitamin A

 D

Niacin

Ans. A

Explanation:

 

  • Vitamin C is required for collagen synthesis.
  • Due to its important role in collagen synthesis, vitamin C is required for adequate wound healing.

Q. 6

False about wound healing ‑

 A

Inhibited by infection

 B

Inhibited by DM

 C

Inhibited by hematoma

 D

Inhibited by foreign body

Q. 6

False about wound healing ‑

 A

Inhibited by infection

 B

Inhibited by DM

 C

Inhibited by hematoma

 D

Inhibited by foreign body

Ans. C

Explanation:

Ans. is ‘c’ i.e., Inhibited by hematoma 

Factors causing impairment of wound healing

A. Systemic factors

  • Poor nutrition (protein deficiency, vitamin C deficiency).
  • Metabolic abnormalities (Diabetes mellitus).
  • Poor circulatory status (Inadequate blood supply).
  • Hormones, e.g. glucocorticoids.

B. Local factors

  • Infection is the single most important factor.
  • Mechanical factors, e.g. early mobilization.
  • Foreign bodies (unnecessary sutures, fragments of steel or glass).
  • Wound in poorly vacularized area, e.g. foot.

Quiz In Between



WOUND HEALING- Complications, Factors & Strength

WOUND HEALING- Complications, Factors & Strength


WOUND HEALING- Complication, Factors & Strength

Complications of Wound Healing-

  • Infections
  • Epidermal cyst
  • Deficient scar formation
  • Incisional hernia
  • Hypertrophied scar
  • Keloid formation
  • Excessive contraction

Wound Strength-

  • Wound contraction- completed by 14th day
  • At the end of 3rd month 70- 80% of normal skin (maximum strength)

 Extracellular Matrix-

  • It has 5 major components
  1. Collagen
  2. Glycoproteins
  3. Basement membrane
  4. Elastic fibres
  5. Proteoglycan
  • Fibroblasts in healing wound are derived from local mesenchyme.
  • Vitamin C promotes wound healing.
  • Vitamin E inhibits wound healing

Exam Important

Complications of Wound Healing-

  • Infection
  • Deficient scar formation
  • Hypertrophied scar
  • Keloid formation

Wound Strength-

  • Wound contraction- completed by 14th day
  • At the end of 3rd month 70- 80% of normal skin (maximum strength)
  • Fibroblasts in healing wound are derived from local mesenchyme.
  • Vitamin C promotes wound healing.
  • Vitamin E inhibits wound healing
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