ERYTHEMA MULTIFORME
| A | Erythema multiforme major | |
| B |
Bullous eruptions |
|
| C |
Toxic epidermal necrosis |
|
| D |
Pyostomatitis vegetans |
After taking sulphonamide group of drugs, one patient developed certain oral lesions. The lesions consist of vesicles, ruptured to form ulcers covered with pseudomembrane. While touching, the lesions bleed easily. Hemorrhagic crusts on lips and other skin lesions are also present.
| A | Both Assertion and Reason are true, and Reason is the correct explanation for Assertion | |
| B |
Both Assertion and Reason are true, and Reason is not the correct explanation for Assertion |
|
| C |
Assertion is true, but Reason is false |
|
| D |
Assertion is false, but Reason is true |
Commonest etiology of erythema multiforme is –
| A |
Viral |
|
| B |
Bacterial |
|
| C |
Food |
|
| D |
Drugs |
Regarding Erythema multiforme all are true except:
| A |
No vesicles |
|
| B |
Target lesions are seen |
|
| C |
Involves face and neck regions |
|
| D |
Sign of internal malignancy |
Which of the following is true about erythema multiforme:
September 2011
| A |
Triggered mainly by HIV infection |
|
| B |
Target lesions are seen |
|
| C |
Full blown prodromal symptoms |
|
| D |
Involvement of mucosa more common |
Erythema multiforme ‑
| A |
Staphylococcus |
|
| B |
TB |
|
| C |
HSV |
|
| D |
EBV |
Erythema multiforme is most commonly caused by‑
| A |
Herpes simplex |
|
| B |
Idiopathic |
|
| C |
TB |
|
| D |
Drugs |
The most clinically significant skin eruption associated with M. pneumoniae infection is:
| A |
Erythema multiforme major |
|
| B |
Bullous eruptions |
|
| C |
Toxic epidermal necrosis |
|
| D |
Pyostomatitis vegetans |
Erythema multiforme major (Stevens-Johnson syndrome) is the most clinically significant skin eruption associated with M. pneumoniae infection.
After taking sulphonamide group of drugs, one patient developed certain oral lesions. The lesions consist of vesicles, ruptured to form ulcers covered with pseudomembrane. While touching, the lesions bleed easily. Hemorrhagic crusts on lips and other skin lesions are also present.
| A | Both Assertion and Reason are true, and Reason is the correct explanation for Assertion | |
| B |
Both Assertion and Reason are true, and Reason is not the correct explanation for Assertion |
|
| C |
Assertion is true, but Reason is false |
|
| D |
Assertion is false, but Reason is true |
Erythema multiforme is a disease of rapid onset involving the skin and mucous membranes.
It is associated with drug allergy or recent herpes simplex infection. Hemorrhagic crusts on the lips is a distinctive form.
ETIOLOGY:
- Idiopathic: A most common cause
- Viral: HSV (most important) HBV, Mumps, Adenovirus
- Bacteria: Streptococci, tuberculosis, M. pneumoniae
- Fungal: Coccidioidomycosis, Histoplasmosis.
- Drugs -: Antibiotics (Sulphonamide), Phenytoin, NSAIDs.
- Autoimmune disease: SLE, thyroiditis, RA
- Others: Sarcoidosis, Pregnancy, Malignancy.
- LIPS – Mucosal (Erosions / Vesicles / Bullae)
- GINGIVAL / Ventral Tongue
- Hard Palate – Spared
- Pharynx / Larynx / Trachea / Bronchi
- Conjunctivitis B/L with Vesicles / Erosions
- Nasal / Urethral / Anal Mucosae
- 2/3 Mucosal Sites sans Cutaneous inv – FUCH’s SYNDROME
The disease is self-limiting and management is mainly supportive. Steroids are used to treat the severe form.
| A | Viral | |
| B |
Bacterial |
|
| C |
Food |
|
| D |
Drugs |
A. i.e. Viral
Regarding Erythema multiforme all are true except:
| A |
No vesicles |
|
| B |
Target lesions are seen |
|
| C |
Involves face and neck regions |
|
| D |
Sign of internal malignancy |
A i.e. No vesicle
Erythema multiforme is caused mostly because of virus (herpes simplex virus 1(2) or rarely d/t drugs (sulfonamides mc) and internal malignancies Q. Characteristic target (iris/bull’s eye/annular) lesions is purpuric, erythematous-papulo-vesicular lesion resembling target of shooting range Q. It first appears acrally & then spread in a centripetal manner to symmetrically involve extensor surface of extremities (hand, feet, elbow, knee), face & neck Q. Mucosa is involved in 70% cases.
Which of the following is true about erythema multiforme:
September 2011
| A |
Triggered mainly by HIV infection |
|
| B |
Target lesions are seen |
|
| C |
Full blown prodromal symptoms |
|
| D |
Involvement of mucosa more common |
Ans. B: Target lesions are seen
“Erythema” in dermatology:
- Erythema induratum: Bazins disease
- Erythema nodosum: Multisystemic disorders e.g. sarcoidosis Erythema chronicum migrans: Lymes disease
| A | Staphylococcus | |
| B |
TB |
|
| C |
HSV |
|
| D |
EBV |
Ans. is ‘c’ i.e., HSV
- Idiopathic erythema multiforme is the most common cause of EM. o Herpes simplex is the most important infectious cause of EM.
Causes of Erythema multiforme
- Idiopathic —> Most common cause
- Viral –> HSV (most important) HBV, Mumps, Adenovirus o Bacteria -9 Streptococci, tuberculosis
- Fungal –> Coccidioidomycosis, Histoplasmosis.
- Drugs —-> Antibiotics (Sulphonamide), Phenytoin, NSAIDS. o Autoimmune disease –> SLE, thyroiditis, RA
- Others —> Sarcoidosis, Pregnancy, Malignancy
| A | Herpes simplex | |
| B |
Idiopathic |
|
| C |
TB |
|
| D |
Drugs |
Ans. is ‘b’ i.e., Idiopathic
- Idiopathic erythema multiforme is the most common cause of EM.
- Herpes simplex is the most important infectious cause of EM.
Causes of Erythema multiforme
- Idiopathic —) Most common cause
- Viral —> HSV (most important) HBV, Mumps, Adenovirus
- Bacteria → Streptococci, tuberculosis
- Fungal —> Coccidioidomycosis, Histoplasmosis.
- Drugs —> Antibiotics (Sulphonamide), Phenytoin, NSAIDS.
- Autoimmune disease —> SLE, thyroiditis, RA
- Others —> Sarcoidosis, Pregnancy, Malignancy.