Leukotriene Antagonist
| A |
Competitive inhibitor of leukotriene synthesis |
|
| B |
Inhibits alpha receptor |
|
| C |
Beta receptor agonist |
|
| D |
Non-competitive inhibitor of leukotriene synthesis |
| A | Inhibition of leukotriene production | |
| B | Inhibits alpha receptors | |
| C | Beta receptor agonist | |
| D | Phosphodiesterase inhibition |
| A | Montelukast | |
| B |
Zileuton |
|
| C |
Omahzumab |
|
| D |
Nedocromil |
The leukotriene receptor antagonist used in bronchial asthma is:
| A |
Zafirleukast |
|
| B |
Zileuton |
|
| C |
Ketotifen |
|
| D |
Omalizumab |
A child was given leukotriene receptor antagonist for prophylaxis of asthma. The drug is –
| A |
Monteleukast |
|
| B |
Zileuton |
|
| C |
Nedocromil |
|
| D |
Verpami I |
Leukotrienes inhibitors are very effective in which one of the following conditions-
| A |
Exercise induced asthma |
|
| B |
Antigen induced asthma |
|
| C |
Aspirin induced asthma |
|
| D |
Occupational asthma |
Leukotriene antagonists is:
March 2009
| A |
Nicordanil |
|
| B |
Zileuton |
|
| C |
Sodium chromoglycate |
|
| D |
Montelukast |
The following drugs can be used for the management of status asthmaticus EXCEPT:
September 2012
| A |
Magnesium sulphate |
|
| B |
Montelukast |
|
| C |
Corticosteroid |
|
| D |
Adrenaline |
Montelukast is ‑
| A |
Leukotriene antagonist |
|
| B |
Potassium channel opener |
|
| C |
Smooth muscle relaxant |
|
| D |
Anti – inflammatory |
| A |
Competitive inhibitor of leukotriene synthesis |
|
| B |
Inhibits alpha receptor |
|
| C |
Beta receptor agonist |
|
| D |
Non-competitive inhibitor of leukotriene synthesis |
Competitive inhibitor of leukotriene synthesis REF: Goodman and Gillman’s 11′ edition p. 478
“Zafirlukast and Montelukast are leukotriene receptor antagonists. Leukotriene-modifying drugs act either as competitive antagonist of leukotriene receptors or by inhibiting the synthesis of leukotriene”
| A | Inhibition of leukotriene production | |
| B | Inhibits alpha receptors | |
| C | Beta receptor agonist | |
| D | Phosphodiesterase inhibition |
Which of the following is a leukotriene antagonist?
| A |
Montelukast |
|
| B |
Zileuton |
|
| C |
Omahzumab |
|
| D |
Nedocromil |
Out of all the given options, Montelukast is a leukotriene antagonist.
Ref: K D Tripathi Textbook of Pharmacology, 5th Edition, Page 205; Modern Pharmacology With Clinical Applications By Charles R. Craig, Robert E. Stitzel, Pages 465-67
The leukotriene receptor antagonist used in bronchial asthma is:
| A |
Zafirleukast |
|
| B |
Zileuton |
|
| C |
Ketotifen |
|
| D |
Omalizumab |
Among the options given only Zafirleukast is leukotriene receptor antagonist. Zileuton is a 5-Lipoxygenase inhibitor, Ketotifen is an antihistaminic (H1) and Omalizumab is a recombinant humanized monoclonal anti-IgE antibody.
Ref: Bronchial Asthma: A Guide for Practical Understanding and Treatment, Springer, 2011, Page 193; Current Review of Asthma, By Michael A. Kaliner – Page 216; Essentials of Medical Pharmacology, KD Tripathi – 5th Edition, Page 205-206; Katzung & Trevor’s Pharmacology 10th Edition, Page 325.
A child was given leukotriene receptor antagonist for prophylaxis of asthma. The drug is –
| A |
Monteleukast |
|
| B |
Zileuton |
|
| C |
Nedocromil |
|
| D |
Verpami I |
Ans. is ‘a’ i.e., Monteleukast
o Monteleukast and zafirleucast are cystenyl LT, (cys LT,) receptor antagonists.
Leukotrienes inhibitors are very effective in which one of the following conditions-
| A |
Exercise induced asthma |
|
| B |
Antigen induced asthma |
|
| C |
Aspirin induced asthma |
|
| D |
Occupational asthma |
Ans. is ‘c’ i.e., Aspirin induced asthma
o Leukotrienes antagonists are effective in aspirin induced asthma.
Leukotriene antagonists is:
March 2009
| A |
Nicordanil |
|
| B |
Zileuton |
|
| C |
Sodium chromoglycate |
|
| D |
Montelukast |
Ans. D: Montelukast
It is usually administered orally.
Montelukast is a CysLT1 antagonist; that is it blocks the action of leukotriene D4 (and secondary ligands LTC4 and LTE4) on the cysteinyl leukotriene receptor CysLT1 in the lungs and bronchial tubes by binding to it.
This reduces the bronchoconstriction otherwise caused by the leukotriene, and results in less inflammation.
Because of its method of operation, it is not useful for the treatment of acute asthma attacks. Again because of its very specific focus of operation, it does not interact with other allergy medications such as theophylline.
Another leukotriene receptor antagonist is zafirlukast.
Zileuton, an asthma drug, blocks leukotriene synthesis by inhibiting 5-lipoxygenase, an enzyme of the eicosanoid synthesis pathway
September 2012
| A | Magnesium sulphate | |
| B |
Montelukast |
|
| C |
Corticosteroid |
|
| D |
Adrenaline |
Ans. B i.e. Montelukast
Montelukast is ‑
| A |
Leukotriene antagonist |
|
| B |
Potassium channel opener |
|
| C |
Smooth muscle relaxant |
|
| D |
Anti – inflammatory |
Ans. is ‘a’ i.e., Leukotriene antagonist
Leukotriene antagonists
- Monteleukast and zafirleucast are cystenyl LT, (cys LT1) receptor antagonists.
- They are indicated for prophylactic therapy of mild to moderate asthma as alternatives to inhaled glucocorticoids.
- They are more acceptable in children.
- They are not used for terminating asthma episodes.
- They are effective in aspirin induced asthma.
- They are very safe drugs, produce few side effects like headache and rashes.
- Eosinophilia, neuropathy and churg-strauss syndrome are other rare side effects.