Question
Loading dose of an oral drug depends on all of the following except?
| A. |
Volume of distribution |
| B. |
Plasma concentration |
| C. |
Half-life |
| D. |
Bioavailability |
Show Answer
|
Correct Answer » C Explanation |
 |
Loading dose is calculated to rapidly achieve the desired plasma concentration.
Loading Dose Formula
Loading dose = (Vd × Target plasma concentration) / F
Where:
- Vd = Volume of distribution
- F = Bioavailability
Maintenance Dose Depends On
- Clearance
- Desired steady-state concentration
- Dosing interval
Half-life does NOT determine loading dose.
- Half-life affects:
- Time to reach steady state
- Maintenance dosing interval
- It does not affect the amount of loading dose required.