Question
A person with jaundice presented with a history of bleeding, and symptoms normalized after giving vitamin K injection. The probable cause is?
| A. |
Biliary obstruction |
| B. |
Alpha-1 antitrypsin deficiency |
| C. |
Autoimmune hepatitis |
| D. |
Factor XI deficiency |
|
Correct Answer � A Explanation |
 |
Vitamin K is fat-soluble & needs bile salts for absorption. In biliary obstruction, impaired bile flow → malabsorption of fat-soluble vitamins, particularly vitamin K. This → deficiency of vitamin K-dependent clotting factors (II, VII, IX, X), causing bleeding. Parenteral vitamin K bypasses absorption issues, correcting coagulopathy quickly.
Incorrect Options:
B: Alpha-1 antitrypsin deficiency affects liver & lungs, not correctable with vitamin K.
C: Autoimmune hepatitis causes coagulopathy, not rapidly fixed by vitamin K alone.
D: Factor XI deficiency is congenital, unrelated to vitamin K or bile function.