Question
Out of the following areas of brain, which area is most commonly affected on brain imaging in Wilson’s disease?
| A. |
Cerebellum |
| B. |
Sub-cortex |
| C. |
Thalamus |
| D. |
Basal ganglia |
|
Correct Answer � D Explanation |
 |
– Wilson’s disease is an autosomal recessive copper metabolism disorder.
– Causes copper buildup in liver, brain, cornea, and kidneys.
– Neurological issues arise from copper in the basal ganglia, especially in the putamen, globus pallidus, and caudate nucleus.
Imaging findings:
– MRI is more sensitive than CT.
– Basal ganglia (putamen) is the most affected site.
– Thalamus, midbrain, cerebellum can also be involved.
– “Face of the giant panda” sign on T2 MRI indicates midbrain changes.
Incorrect Options:
– A. Cerebellum: Less commonly affected; leads to tremor & gait issues.
– B. Subcortex: Rare white matter changes in advanced stages.
– C. Thalamus: Involvement is secondary, not primary.