Question
Which of the following statements about changes in articular cartilage with aging is not TRUE?
| A. |
Total proteoglycan content is decreased |
| B. |
Synthesis of proteoglycans is decreased |
| C. |
Total water content of cartilage is decreased |
| D. |
Enzymatic degradation of proteoglycans is increased |
Show Answer
|
Correct Answer � D Explanation |
 |
In ageing there will be no increase in enzymatic degradation of proteoglycans. The enzymatic degradation is slow and constant throughout the life.
Ref: Biology of Cartilage Cells, Stockwell, R.A, 1976, 1st Edition, Page 245; Osteoarthritis : A companion to Rheumatology, Elsevier, 1st Edition, 2007, Page 79.