Question
The main component of hyperlipidemia constituting a major risk factor for atherosclerosis is-
| A. |
High densely lipoprotein (HDL) cholesterol |
| B. |
Intermediate densely lipoprotein (IDL) cholesterol |
| C. |
Low densely lipoprotein (LDL) cholesterol |
| D. |
Very low density lipoprotein (VLDL) cholesterol |
|
Correct Answer » C Explanation |
 |
LDL cholesterol is the primary atherogenic lipoprotein.
It delivers cholesterol to peripheral tissues.
Excess LDL undergoes oxidation, is taken up by macrophages, which form foam cells, leading to fatty streaks & plaques.
Incorrect Options:
– HDL: “Good cholesterol,” promotes reverse cholesterol transport, protective.
– IDL: Intermediate between VLDL & LDL, less contribution to atherosclerosis.
– VLDL: Carries triglycerides, precursor to LDL, less important than LDL.
Atherosclerosis pathogenesis:
– Endothelial injury → LDL oxidation → foam cell formation → fatty streak → plaque.