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MCQ – 197

amit18289

Question

Testicular feminization syndrome is associated with :
A.

46 XX
B.

presence of vagina
C.

Primary amenorrhea
D.

Short stature
Show Answer

Correct Answer � C

Explanation

Ans. is C. i.e. Primary amenorrhea

  • In Testicular Feminising Syndrome also k/an Androgen insensitivity syndrome defect lies in the outflow tract of the uterus.
  • It is one of the etiological factors of primary Amenorrhea.
  • The height of the patient is normal and the vagina is absent.
  • The karyotype is XY.
  • Etiology of Primary Amenorrhea
Compartment I (Disorders of outflow tract uterus)
  • Mullerian Anomalies

(2nd M/c cause of primary amenorrhea)

  • Androgen insensitivity syndrome

(Testicular feminization syndrome)

Compartment II (Disorders of Ovary)
  • Gonadal dysgenesis

(M/c cause of Primary Amenorrhea)

  • Turners syndrome: 45XO
  • Pure gonadal dysgenesis: 46 XX
  • Swyers syndrome: 46 XY
  • Savage syndrome: Resistant ovary syndrome
Compartment III (Disorders of Anterior Pituitary)
  • Neoplasia
  • Prolactinomas/Craniopharyngiomas
  • Hypopituitary states – Simmond’s disease/Chiari-Frommel syndrome
  • Forbes Albright syndrome (Not very important)
Compartment IV (Disorders of CNS)
  • Kallmann syndrome (Amenorrhea + Anosmia)
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